GDF-15 as a Therapeutic Target of Diabetic Complications Increases the Risk of Gallstone Disease: Mendelian Randomization and Polygenic Risk Score Analysis

Growth differentiation factor 15 (GDF-15) levels have been revealed as a robust biomarker for metformin use. We conducted Mendelian randomization (MR) analysis to explore the association between GDF-15 and gallstone disease to inform potential therapeutic effects targeting GDF-15. Four genetic varia...

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Detalles Bibliográficos
Autores principales: Yu, Lili, Zhou, Yajing, Wang, Lijuan, Zhou, Xuan, Sun, Jing, Xiao, Jiarui, Xu, Xiaolin, Larsson, Susanna C., Yuan, Shuai, Li, Xue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234303/
https://www.ncbi.nlm.nih.gov/pubmed/35769993
http://dx.doi.org/10.3389/fgene.2022.814457

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234303/
https://www.ncbi.nlm.nih.gov/pubmed/35769993
http://dx.doi.org/10.3389/fgene.2022.814457

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