Quantification of transgene expression in GSH AAVS1 with a novel CRISPR/Cas9-based approach reveals high transcriptional variation

Genomic safe harbors (GSH) are defined as sites in the host genome that allow stable expression of inserted transgenes while having no adverse effects on the host cell, making them ideal for use in basic research and therapeutic applications. Silencing and fluctuations in transgene expression would...

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Detalles Bibliográficos
Autores principales: Inderbitzin, Anne, Loosli, Tom, Kouyos, Roger D., Metzner, Karin J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234542/
https://www.ncbi.nlm.nih.gov/pubmed/35795775
http://dx.doi.org/10.1016/j.omtm.2022.06.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234542/
https://www.ncbi.nlm.nih.gov/pubmed/35795775
http://dx.doi.org/10.1016/j.omtm.2022.06.003

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