The Human SCN9A(R185H) Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice

The voltage-gated sodium channel Nav1.7 is encoded by SCN9A gene and plays a critical role in pain sensitivity. Several SCN9A gain-of-function (GOF) mutations have been found in patients with small fiber neuropathy (SFN) having chronic pain, including the R185H mutation. However, for most of these v...

Descripción completa

Detalles Bibliográficos
Autores principales: Xue, Yaping, Kremer, Mélanie, Muniz Moreno, Maria del Mar, Chidiac, Celeste, Lorentz, Romain, Birling, Marie-Christine, Barrot, Michel, Herault, Yann, Gaveriaux-Ruff, Claire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234669/
https://www.ncbi.nlm.nih.gov/pubmed/35769334
http://dx.doi.org/10.3389/fnmol.2022.913990

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234669/
https://www.ncbi.nlm.nih.gov/pubmed/35769334
http://dx.doi.org/10.3389/fnmol.2022.913990

Ejemplares similares