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The Human SCN9A(R185H) Point Mutation Induces Pain Hypersensitivity and Spontaneous Pain in Mice
The voltage-gated sodium channel Nav1.7 is encoded by SCN9A gene and plays a critical role in pain sensitivity. Several SCN9A gain-of-function (GOF) mutations have been found in patients with small fiber neuropathy (SFN) having chronic pain, including the R185H mutation. However, for most of these v...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234669/ https://www.ncbi.nlm.nih.gov/pubmed/35769334 http://dx.doi.org/10.3389/fnmol.2022.913990 |