The developmental stage of the medulloblastoma cell-of-origin restricts Sonic hedgehog pathway usage and drug sensitivity

Sonic hedgehog (SHH) medulloblastoma originates from the cerebellar granule neuron progenitor (CGNP) lineage, which depends on Hedgehog signaling for its perinatal expansion. Whereas SHH tumors exhibit overall deregulation of this pathway, they also show patient age-specific aberrations. To investig...

Descripción completa

Detalles Bibliográficos
Autores principales: Smit, Marlinde J., Martini, Tosca E. I., Armandari, Inna, Bočkaj, Irena, Zomerman, Walderik W., de Camargo Magalhães, Eduardo S., Siragna, Zillah, Meeuwsen, Tiny G. J., Scherpen, Frank J. G., Schoots, Mirthe H., Ritsema, Martha, den Dunnen, Wilfred F. A., Hoving, Eelco W., Paridaen, Judith T. M. L., de Haan, Gerald, Guryev, Victor, Bruggeman, Sophia W. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Company of Biologists Ltd 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234672/
https://www.ncbi.nlm.nih.gov/pubmed/35535520
http://dx.doi.org/10.1242/jcs.258608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234672/
https://www.ncbi.nlm.nih.gov/pubmed/35535520
http://dx.doi.org/10.1242/jcs.258608

Ejemplares similares