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Efficient silencing of hepatitis B virus S gene through CRISPR‐mediated base editing

Hepatitis B virus (HBV) infection is a major risk factor of liver cirrhosis and hepatocellular carcinoma. Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR‐associated protein 9 (Cas9) has been used to precisely edit the HBV genome and eliminate HBV through non‐homologous end‐...

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Detalles Bibliográficos
Autores principales: Zhou, Hao, Wang, Xiaomei, Steer, Clifford J., Song, Guisheng, Niu, Junqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234685/
https://www.ncbi.nlm.nih.gov/pubmed/35338607
http://dx.doi.org/10.1002/hep4.1933