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Dynamic spectrum of ectopic lymphoid B cell activation and hypermutation in the RA synovium characterized by NR4A nuclear receptor expression
Ectopic lymphoid structures (ELS) can develop in rheumatoid arthritis (RA) synovial tissue, but the precise pathways of B cell activation and selection are not well understood. Here, we identify a synovial B cell population characterized by co-expression of a family of orphan nuclear receptors (NR4A...
Autores principales: | Meednu, Nida, Rangel-Moreno, Javier, Zhang, Fan, Escalera-Rivera, Katherine, Corsiero, Elisa, Prediletto, Edoardo, DiCarlo, Edward, Goodman, Susan, Donlin, Laura T., Raychauduri, Soumya, Bombardieri, Michele, Pitzalis, Costantino, Orange, Dana E., McDavid, Andrew, Anolik, Jennifer H. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9234997/ https://www.ncbi.nlm.nih.gov/pubmed/35508128 http://dx.doi.org/10.1016/j.celrep.2022.110766 |
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