OPUSeq simplifies detection of low-frequency DNA variants and uncovers fragmentase-associated artifacts

Detection of low-frequency DNA variants (below 1%) is becoming increasingly important in biomedical research and clinical practice, but is challenging to do with standard sequencing approaches due to high error rates. The use of double-stranded unique molecular identifiers (dsUMIs) allows correction...

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Detalles Bibliográficos
Autores principales: Alekseenko, Alisa, Wang, Jingwen, Barrett, Donal, Pelechano, Vicent
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
High Throughput Sequencing Methods
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235115/
https://www.ncbi.nlm.nih.gov/pubmed/35769342
http://dx.doi.org/10.1093/nargab/lqac048

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235115/
https://www.ncbi.nlm.nih.gov/pubmed/35769342
http://dx.doi.org/10.1093/nargab/lqac048

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