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OPUSeq simplifies detection of low-frequency DNA variants and uncovers fragmentase-associated artifacts
Detection of low-frequency DNA variants (below 1%) is becoming increasingly important in biomedical research and clinical practice, but is challenging to do with standard sequencing approaches due to high error rates. The use of double-stranded unique molecular identifiers (dsUMIs) allows correction...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235115/ https://www.ncbi.nlm.nih.gov/pubmed/35769342 http://dx.doi.org/10.1093/nargab/lqac048 |