A multi-pronged evaluation of aldehyde-based tripeptidyl main protease inhibitors as SARS-CoV-2 antivirals

As an essential enzyme of SARS-CoV-2, the COVID-19 pathogen, main protease (M(Pro)) is a viable target to develop antivirals for the treatment of COVID-19. By varying chemical compositions at both P2 and P3 positions and the N-terminal protection group, we synthesized 18 tripeptidyl M(Pro) inhibitor...

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Detalles Bibliográficos
Autores principales: Ma, Yuying, Yang, Kai S., Geng, Zhi Zachary, Alugubelli, Yugendar R., Shaabani, Namir, Vatansever, Erol C., Ma, Xinyu R., Cho, Chia-Chuan, Khatua, Kaustav, Xiao, Jing, Blankenship, Lauren R., Yu, Ge, Sankaran, Banumathi, Li, Pingwei, Allen, Robert, Ji, Henry, Xu, Shiqing, Liu, Wenshe Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Masson SAS. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235293/
https://www.ncbi.nlm.nih.gov/pubmed/35779291
http://dx.doi.org/10.1016/j.ejmech.2022.114570

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235293/
https://www.ncbi.nlm.nih.gov/pubmed/35779291
http://dx.doi.org/10.1016/j.ejmech.2022.114570

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