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MeConcord: a new metric to quantitatively characterize DNA methylation heterogeneity across reads and CpG sites

MOTIVATION: Intermediately methylated regions occupy a significant fraction of the human genome and are closely associated with epigenetic regulations or cell-type deconvolution of bulk data. However, these regions show distinct methylation patterns, corresponding to different biological mechanisms....

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Detalles Bibliográficos
Autores principales: Zhang, Xianglin, Wang, Xiaowo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235486/
https://www.ncbi.nlm.nih.gov/pubmed/35758820
http://dx.doi.org/10.1093/bioinformatics/btac248