Engineering death resistance in CHO cells for improved perfusion culture

The reliable and cost-efficient manufacturing of monoclonal antibodies (mAbs) is essential to fulfil their ever-growing demand. Cell death in bioreactors reduces productivity and product quality, and is largely attributed to apoptosis. In perfusion bioreactors, this leads to the necessity of a bleed...

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Detalles Bibliográficos
Autores principales: MacDonald, Michael A., Nöbel, Matthias, Martínez, Verónica S., Baker, Kym, Shave, Evan, Gray, Peter P., Mahler, Stephen, Munro, Trent, Nielsen, Lars K., Marcellin, Esteban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2022
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235890/
https://www.ncbi.nlm.nih.gov/pubmed/35737825
http://dx.doi.org/10.1080/19420862.2022.2083465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9235890/
https://www.ncbi.nlm.nih.gov/pubmed/35737825
http://dx.doi.org/10.1080/19420862.2022.2083465

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