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Mathematical modeling of the microtubule detyrosination/tyrosination cycle for cell-based drug screening design
Microtubules and their post-translational modifications are involved in major cellular processes. In severe diseases such as neurodegenerative disorders, tyrosinated tubulin and tyrosinated microtubules are in lower concentration. We present here a mechanistic mathematical model of the microtubule t...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236252/ https://www.ncbi.nlm.nih.gov/pubmed/35759459 http://dx.doi.org/10.1371/journal.pcbi.1010236 |