TUBA1A tubulinopathy mutants disrupt neuron morphogenesis and override XMAP215/Stu2 regulation of microtubule dynamics

Heterozygous, missense mutations in α- or β-tubulin genes are associated with a wide range of human brain malformations, known as tubulinopathies. We seek to understand whether a mutation’s impact at the molecular and cellular levels scale with the severity of brain malformation. Here, we focus on t...

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Detalles Bibliográficos
Autores principales: Hoff, Katelyn J, Aiken, Jayne E, Gutierrez, Mark A, Franco, Santos J, Moore, Jeffrey K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236607/
https://www.ncbi.nlm.nih.gov/pubmed/35511030
http://dx.doi.org/10.7554/eLife.76189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236607/
https://www.ncbi.nlm.nih.gov/pubmed/35511030
http://dx.doi.org/10.7554/eLife.76189

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