Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion

TMEM16F, a Ca(2+)-activated phospholipid scramblase (CaPLSase), is critical for placental trophoblast syncytialization, HIV infection, and SARS-CoV2-mediated syncytialization, however, how TMEM16F is activated during cell fusion is unclear. Here, using trophoblasts as a model for cell fusion, we dem...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, Liang, Pengfei, Yang, Liheng, Shan, Ke Zoe, Feng, Liping, Chen, Yong, Liedtke, Wolfgang, Coyne, Carolyn B, Yang, Huanghe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236608/
https://www.ncbi.nlm.nih.gov/pubmed/35670667
http://dx.doi.org/10.7554/eLife.78840

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236608/
https://www.ncbi.nlm.nih.gov/pubmed/35670667
http://dx.doi.org/10.7554/eLife.78840

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