Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number

Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle. This control is achieved by multiple mechanisms, including the regulation of the protein kinase PLK4, the most ups...

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Detalles Bibliográficos
Autores principales: Tkach, Johnny M, Philip, Reuben, Sharma, Amit, Strecker, Jonathan, Durocher, Daniel, Pelletier, Laurence
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236612/
https://www.ncbi.nlm.nih.gov/pubmed/35758262
http://dx.doi.org/10.7554/eLife.73944

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236612/
https://www.ncbi.nlm.nih.gov/pubmed/35758262
http://dx.doi.org/10.7554/eLife.73944

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