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Global cellular response to chemical perturbation of PLK4 activity and abnormal centrosome number
Centrosomes act as the main microtubule organizing center (MTOC) in metazoans. Centrosome number is tightly regulated by limiting centriole duplication to a single round per cell cycle. This control is achieved by multiple mechanisms, including the regulation of the protein kinase PLK4, the most ups...
Autores principales: | Tkach, Johnny M, Philip, Reuben, Sharma, Amit, Strecker, Jonathan, Durocher, Daniel, Pelletier, Laurence |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236612/ https://www.ncbi.nlm.nih.gov/pubmed/35758262 http://dx.doi.org/10.7554/eLife.73944 |
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