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Cytotoxic CD4(+) T cells driven by T-cell intrinsic IL-18R/MyD88 signaling predominantly infiltrate Trypanosoma cruzi-infected hearts
Increasing attention has been directed to cytotoxic CD4(+) T cells (CD4CTLs) in different pathologies, both in humans and mice. The impact of CD4CTLs in immunity and the mechanisms controlling their generation, however, remain poorly understood. Here, we show that CD4CTLs abundantly differentiate du...
Autores principales: | Barbosa, Carlos-Henrique D, Canto, Fábio B, Gomes, Ariel, Brandao, Layza M, Lima, Jéssica R, Melo, Guilherme A, Granato, Alessandra, Neves, Eula GA, Dutra, Walderez O, Oliveira, Ana-Carolina, Nóbrega, Alberto, Bellio, Maria |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236613/ https://www.ncbi.nlm.nih.gov/pubmed/35670567 http://dx.doi.org/10.7554/eLife.74636 |
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