Frequency and mechanisms of LINE-1 retrotransposon insertions at CRISPR/Cas9 sites

CRISPR/Cas9-based genome editing has revolutionized experimental molecular biology and entered the clinical world for targeted gene therapy. Identifying DNA modifications occurring at CRISPR/Cas9 target sites is critical to determine efficiency and safety of editing tools. Here we show that insertio...

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Detalles Bibliográficos
Autores principales: Tao, Jianli, Wang, Qi, Mendez-Dorantes, Carlos, Burns, Kathleen H., Chiarle, Roberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237045/
https://www.ncbi.nlm.nih.gov/pubmed/35760782
http://dx.doi.org/10.1038/s41467-022-31322-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237045/
https://www.ncbi.nlm.nih.gov/pubmed/35760782
http://dx.doi.org/10.1038/s41467-022-31322-3

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