The importance of DNAPKcs for blunt DNA end joining is magnified when XLF is weakened

Canonical non-homologous end joining (C-NHEJ) factors can assemble into a long-range (LR) complex with DNA ends relatively far apart that contains DNAPKcs, XLF, XRCC4, LIG4, and the KU heterodimer and a short-range (SR) complex lacking DNAPKcs that has the ends positioned for ligation. Since the SR...

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Detalles Bibliográficos
Autores principales: Cisneros-Aguirre, Metztli, Lopezcolorado, Felicia Wednesday, Tsai, Linda Jillianne, Bhargava, Ragini, Stark, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237100/
https://www.ncbi.nlm.nih.gov/pubmed/35760797
http://dx.doi.org/10.1038/s41467-022-31365-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237100/
https://www.ncbi.nlm.nih.gov/pubmed/35760797
http://dx.doi.org/10.1038/s41467-022-31365-6

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