DNA-Compatible Suzuki-Miyaura Cross-Coupling Reaction of Aryl Iodides With (Hetero)Aryl Boronic Acids for DNA-Encoded Libraries

An efficient method for the C-C bond formation via water soluble Na(2)PdCl(4)/sSPhos mediated Suzuki-Miyaura cross-coupling reaction of DNA-conjugated aryl iodide with (het)aryl boronic acids has been developed. This reaction proceeds at 37°C in water and acetonitrile (4:1) system. We also demonstra...

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Detalles Bibliográficos
Autores principales: Siripuram, Vijay Kumar, Sunkari, Yashoda Krishna, Nguyen, Thu-Lan, Flajolet, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237475/
https://www.ncbi.nlm.nih.gov/pubmed/35774858
http://dx.doi.org/10.3389/fchem.2022.894603

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237475/
https://www.ncbi.nlm.nih.gov/pubmed/35774858
http://dx.doi.org/10.3389/fchem.2022.894603

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