Aging-Dependent Altered Transcriptional Programs Underlie Activity Impairments in Human C9orf72-Mutant Motor Neurons

Amyotrophic Lateral Sclerosis (ALS) is an incurable neurodegenerative disease characterized by dysfunction and loss of upper and lower motor neurons (MN). Despite several studies identifying drastic alterations affecting synaptic composition and functionality in different experimental models, the sp...

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Detalles Bibliográficos
Autores principales: Sommer, Daniel, Rajkumar, Sandeep, Seidel, Mira, Aly, Amr, Ludolph, Albert, Ho, Ritchie, Boeckers, Tobias M., Catanese, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237792/
https://www.ncbi.nlm.nih.gov/pubmed/35774867
http://dx.doi.org/10.3389/fnmol.2022.894230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237792/
https://www.ncbi.nlm.nih.gov/pubmed/35774867
http://dx.doi.org/10.3389/fnmol.2022.894230

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