Selectively Fluorinated Citronellol Analogues Support a Hydrogen Bonding Donor Interaction with the Human OR1A1 Olfactory Receptor

[Image: see text] C-2 fluorinated and methylated stereoisomers of the fragrance citronellol 1 and its oxalate esters were prepared from (R)-pulegone 11 and explored as agonists of the human olfactory receptor OR1A1 and assayed also against site-specific mutants. There were clear isomer preferences a...

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Detalles Bibliográficos
Autores principales: He, Mengfan, Liu, Weihong, Zhang, Chen, Liu, Yingjian, Zhuang, Hanyi, O’Hagan, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237825/
https://www.ncbi.nlm.nih.gov/pubmed/35686936
http://dx.doi.org/10.1021/acs.orglett.2c01635

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237825/
https://www.ncbi.nlm.nih.gov/pubmed/35686936
http://dx.doi.org/10.1021/acs.orglett.2c01635

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