Optimization of the TeraTox Assay for Preclinical Teratogenicity Assessment

Current animal-free methods to assess teratogenicity of drugs under development still deliver high numbers of false negatives. To improve the sensitivity of human teratogenicity prediction, we characterized the TeraTox test, a newly developed multilineage differentiation assay using 3D human-induced...

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Detalles Bibliográficos
Autores principales: Jaklin, Manuela, Zhang, Jitao David, Schäfer, Nicole, Clemann, Nicole, Barrow, Paul, Küng, Erich, Sach-Peltason, Lisa, McGinnis, Claudia, Leist, Marcel, Kustermann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Developmental and Reproductive Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237991/
https://www.ncbi.nlm.nih.gov/pubmed/35485993
http://dx.doi.org/10.1093/toxsci/kfac046

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237991/
https://www.ncbi.nlm.nih.gov/pubmed/35485993
http://dx.doi.org/10.1093/toxsci/kfac046

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