Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

Calcitonin gene-related peptide (CGRP) signaling inhibitors have shown efficacy in both the acute and preventive treatment of migraine. Telcagepant, a first-generation CGRP receptor antagonist, was effective but failed in clinical trials due to hepatotoxicity. Subsequently, although 4 next-generatio...

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Detalles Bibliográficos
Autores principales: Woodhead, Jeffrey L, Siler, Scott Q, Howell, Brett A, Watkins, Paul B, Conway, Charles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Molecular, Biochemical, and Systems Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237996/
https://www.ncbi.nlm.nih.gov/pubmed/35556143
http://dx.doi.org/10.1093/toxsci/kfac051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237996/
https://www.ncbi.nlm.nih.gov/pubmed/35556143
http://dx.doi.org/10.1093/toxsci/kfac051

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