Cargando…

Comparing the Liver Safety Profiles of 4 Next-Generation CGRP Receptor Antagonists to the Hepatotoxic CGRP Inhibitor Telcagepant Using Quantitative Systems Toxicology Modeling

Calcitonin gene-related peptide (CGRP) signaling inhibitors have shown efficacy in both the acute and preventive treatment of migraine. Telcagepant, a first-generation CGRP receptor antagonist, was effective but failed in clinical trials due to hepatotoxicity. Subsequently, although 4 next-generatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Woodhead, Jeffrey L, Siler, Scott Q, Howell, Brett A, Watkins, Paul B, Conway, Charles
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2022
Materias:	Molecular, Biochemical, and Systems Toxicology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237996/ https://www.ncbi.nlm.nih.gov/pubmed/35556143 http://dx.doi.org/10.1093/toxsci/kfac051

Ejemplares similares

Using Quantitative Systems Toxicology to Investigate Observed Species Differences in CKA-Mediated Hepatotoxicity
por: Battista, Christina, et al.
Publicado: (2018)

Respiratory Effects of Exposure to Aerosol From the Candidate Modified-Risk Tobacco Product THS 2.2 in an 18-Month Systems Toxicology Study With A/J Mice
por: Titz, Bjoern, et al.
Publicado: (2020)

2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD)-Inducible Poly-ADP-Ribose Polymerase (TIPARP/PARP7) Catalytic Mutant Mice (Tiparp(H532A)) Exhibit Increased Sensitivity to TCDD-Induced Hepatotoxicity and Lethality
por: Hutin, David, et al.
Publicado: (2021)

New CGRP Antagonists
por: Doods, H. N., et al.
Publicado: (2001)

Safety of Rimegepant, an Oral CGRP Receptor Antagonist, Plus CGRP Monoclonal Antibodies for Migraine
por: Berman, Gary, et al.
Publicado: (2020)

Quizalofop-p-Ethyl Induces Adipogenesis in 3T3-L1 Adipocytes
por: Biserni, Martina, et al.
Publicado: (2019)

Comparative Toxicogenomics of Glyphosate and Roundup Herbicides by Mammalian Stem Cell-Based Genotoxicity Assays and Molecular Profiling in Sprague-Dawley Rats
por: Mesnage, Robin, et al.
Publicado: (2021)

Molecular Dosimetry of DNA Adducts in Rats Exposed to Vinyl Acetate Monomer
por: Hsiao, Yun-Chung, et al.
Publicado: (2021)

Increased sensitivity to chemically induced colitis in mice harboring a DNA-binding deficient aryl hydrocarbon receptor
por: Alvik, Karoline, et al.
Publicado: (2022)

Carvedilol impairs bile acid homeostasis in mice: implication for nonalcoholic steatohepatitis
por: Lastuvkova, Hana, et al.
Publicado: (2023)

Lipidated Calcitonin Gene-Related Peptide (CGRP) Peptide Antagonists Retain CGRP Receptor Activity and Attenuate CGRP Action In Vivo
por: Jamaluddin, Aqfan, et al.
Publicado: (2022)

The CGRP-Antagonist BIBN4096BS Discriminates between the Action of α- and β-CGRP In Vitro
por: Wu, Dongmei, et al.
Publicado: (2001)

Characterization of transit rates in the large intestine of mice following treatment with a CGRP antibody, CGRP receptor antibody, and small molecule CGRP receptor antagonists
por: Johnson, Kirk W., et al.
Publicado: (2022)

CGRP and CGRP receptors in human and rhesus monkey cerebellum
por: Eftekhari, S, et al.
Publicado: (2013)

Next Generation Reproductive and Developmental Toxicology: Crosstalk Into the Future
por: Hougaard, Karin Sørig
Publicado: (2021)

Differential inhibitory response to telcagepant on αCGRP induced vasorelaxation and intracellular Ca(2+) levels in the perfused and non-perfused isolated rat middle cerebral artery
por: Erdling, André, et al.
Publicado: (2017)

CGRP in migraine
por: Tfelt-Hansen, Peer, et al.
Publicado: (2009)

CGRP and migraine
por: Cauchi, M., et al.
Publicado: (2016)

Understanding side-effects of anti-CGRP and anti-CGRP receptor antibodies
por: Haanes, Kristian Agmund, et al.
Publicado: (2020)

Targeted CGRP Small Molecule Antagonists for Acute Migraine Therapy
por: Holland, Philip R., et al.
Publicado: (2018)

Novel Oral CGRP Receptor Antagonist Atogepant in the Prevention of Migraine
por: Chowdhury, Selia, et al.
Publicado: (2023)

Serotonin and CGRP in Migraine
por: Aggarwal, Milan, et al.
Publicado: (2012)

Cgrp Characterization And Classification
por: Marshall, Ian
Publicado: (2001)

CGRP in Primary Headaches
por: Edvinsson, Lars
Publicado: (2001)

Differentiation of nerve fibers storing CGRP and CGRP receptors in the peripheral trigeminovascular system
por: Eftekhari, S, et al.
Publicado: (2013)

The Role of Cgrp-Receptor Component Protein (Rcp) in Cgrp-Mediated Signal Transduction
por: Prado, M. A., et al.
Publicado: (2001)

Effect of CGRP and Related Peptides in the Microcirculation
por: Brain, S. D., et al.
Publicado: (2001)

The Anti-Calcitonin Gene-Related Peptide (Anti-CGRP) Antibody Fremanezumab Reduces Trigeminal Neurons Immunoreactive to CGRP and CGRP Receptor Components in Rats
por: Vogler, Birgit, et al.
Publicado: (2023)

Anti-CGRP Monoclonal Antibodies: the Next Era of Migraine Prevention?
por: Tso, Amy R., et al.
Publicado: (2017)

CGRP outflow into jugular blood and cerebrospinal fluid and permeance for CGRP of rat dura mater
por: Risch, Miriam, et al.
Publicado: (2021)

Change of CGRP Plasma Concentrations in Migraine after Discontinuation of CGRP-(Receptor) Monoclonal Antibodies
por: Raffaelli, Bianca, et al.
Publicado: (2023)

Analyzing the Mechanisms Behind Macrolide Antibiotic-Induced Liver Injury Using Quantitative Systems Toxicology Modeling
por: Woodhead, Jeffrey L., et al.
Publicado: (2019)

A Novel Nonpeptide CGRP Receptor Antagonist, ‘Compound 1’ (WO98/11128) Is a High Affinity Competitive Antagonist at the CGRP1 Receptor in Human Coronary Arteries
por: Hasbak, P., et al.
Publicado: (2001)

Sex Differences in CGRP Regulation and Function in the Amygdala in a Rat Model of Neuropathic Pain
por: Presto, Peyton, et al.
Publicado: (2022)

Gender aspects of CGRP in migraine
por: Labastida-Ramírez, Alejandro, et al.
Publicado: (2017)

CGRP and the Trigeminal System in Migraine
por: Iyengar, Smriti, et al.
Publicado: (2019)

Effect of Xiongmatang Extract on Behavioral and TRPV1-CGRP/CGRP-R Pathway in Rats With Migraine
por: Liu, Dingding, et al.
Publicado: (2022)

Equine feed contamination and toxicology
por: Bischoff, Karyn, et al.
Publicado: (2018)

The effect of the CGRP receptor antagonist (MK-8825) on the response to trigeminal nociception in rodents
por: Romero-Reyes, M, et al.
Publicado: (2013)

A CGRP receptor antagonist peptide formulated for nasal administration to treat migraine
por: von Mentzer, Bengt, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ebbpa7cmjbufrd096aobnbbesf