Targeted BRD4 protein degradation by dBET1 ameliorates acute ischemic brain injury and improves functional outcomes associated with reduced neuroinflammation and oxidative stress and preservation of blood–brain barrier integrity

Bromodomain-containing protein 4 (BRD4), a member of the bromodomain and extra-terminal domain (BET) protein family, plays a crucial role in regulating inflammation and oxidative stress that are tightly related to stroke development and progression. Consequently, BRD4 blockade has attracted increasi...

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Detalles Bibliográficos
Autores principales: Liu, Lei, Yang, Changjun, Lavayen, Bianca P., Tishko, Ryland J., Larochelle, Jonathan, Candelario-Jalil, Eduardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237998/
https://www.ncbi.nlm.nih.gov/pubmed/35761277
http://dx.doi.org/10.1186/s12974-022-02533-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237998/
https://www.ncbi.nlm.nih.gov/pubmed/35761277
http://dx.doi.org/10.1186/s12974-022-02533-8

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