Metformin alleviates osteoarthritis in mice by inhibiting chondrocyte ferroptosis and improving subchondral osteosclerosis and angiogenesis

BACKGROUND: Osteoarthritis (OA) is the most common musculoskeletal disease, and it has a complex pathology and unknown pathogenesis. Chondrocyte ferroptosis is closely associated with the development of OA. As a common drug administered for the treatment of type 2 diabetes, metformin (Met) is known...

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Detalles Bibliográficos
Autores principales: Yan, Jiangbo, Feng, Gangning, Ma, Long, Chen, Zhirong, Jin, Qunhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238069/
https://www.ncbi.nlm.nih.gov/pubmed/35765024
http://dx.doi.org/10.1186/s13018-022-03225-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238069/
https://www.ncbi.nlm.nih.gov/pubmed/35765024
http://dx.doi.org/10.1186/s13018-022-03225-y

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