Leveraging structural and 2D-QSAR to investigate the role of functional group substitutions, conserved surface residues and desolvation in triggering the small molecule-induced dimerization of hPD-L1

Small molecules are rising as a new generation of immune checkpoints’ inhibitors, with compounds targeting the human Programmed death-ligand 1 (hPD-L1) protein are pioneering this area of research. Promising examples include the recently disclosed compounds from Bristol-Myers-Squibb (BMS). These mol...

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Detalles Bibliográficos
Autores principales: Ahmed, Marawan, Ganesan, Aravindhan, Barakat, Khaled
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238240/
https://www.ncbi.nlm.nih.gov/pubmed/35761353
http://dx.doi.org/10.1186/s13065-022-00842-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238240/
https://www.ncbi.nlm.nih.gov/pubmed/35761353
http://dx.doi.org/10.1186/s13065-022-00842-w

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