Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm

BACKGROUND: cGMP‐hydrolyzing phosphodiesterase type 5 (PDE5) regulates vascular smooth muscle cell (SMC) contraction by antagonizing cGMP‐dependent protein kinase I (PKGI)–dependent SMC relaxation. SMC contractile dysfunction is implicated in the pathogenesis of aortic aneurysm. PDE5 inhibitors have...

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Detalles Bibliográficos
Autores principales: Zhang, Chongyang, Mohan, Amy, Shi, Hangchuan, Yan, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238513/
https://www.ncbi.nlm.nih.gov/pubmed/34984916
http://dx.doi.org/10.1161/JAHA.121.023053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238513/
https://www.ncbi.nlm.nih.gov/pubmed/34984916
http://dx.doi.org/10.1161/JAHA.121.023053

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