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Sildenafil (Viagra) Aggravates the Development of Experimental Abdominal Aortic Aneurysm
BACKGROUND: cGMP‐hydrolyzing phosphodiesterase type 5 (PDE5) regulates vascular smooth muscle cell (SMC) contraction by antagonizing cGMP‐dependent protein kinase I (PKGI)–dependent SMC relaxation. SMC contractile dysfunction is implicated in the pathogenesis of aortic aneurysm. PDE5 inhibitors have...
Autores principales: | Zhang, Chongyang, Mohan, Amy, Shi, Hangchuan, Yan, Chen |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238513/ https://www.ncbi.nlm.nih.gov/pubmed/34984916 http://dx.doi.org/10.1161/JAHA.121.023053 |
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