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Modeling the Progression of Cardiac Catecholamine Deficiency in Lewy Body Diseases

BACKGROUND: Lewy body diseases (LBDs) feature deficiency of the sympathetic neurotransmitter norepinephrine in the left ventricular myocardium and sympathetic intra‐neuronal deposition of the protein alpha‐synuclein (αS). LBDs therefore are autonomic synucleinopathies. Computational modeling has rev...

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Detalles Bibliográficos
Autores principales: Goldstein, David S., Pekker, Mark J., Sullivan, Patti, Isonaka, Risa, Sharabi, Yehonatan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238705/
https://www.ncbi.nlm.nih.gov/pubmed/35621196
http://dx.doi.org/10.1161/JAHA.121.024411