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Methadone Blockade of Cardiac Inward Rectifier K(+) Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study
BACKGROUND: Methadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibition of delayed rectifier K(+) current (I (Kr))(,) the principal mechanism of drug‐associated arrhythmia. Congenital defects of inward rectifier K(+) current (I...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238736/ https://www.ncbi.nlm.nih.gov/pubmed/35658478 http://dx.doi.org/10.1161/JAHA.121.023482 |