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Methadone Blockade of Cardiac Inward Rectifier K(+) Current Augments Membrane Instability and Amplifies U Waves on Surface ECGs: A Translational Study

BACKGROUND: Methadone is associated with a disproportionate risk of sudden death and ventricular tachyarrhythmia despite only modest inhibition of delayed rectifier K(+) current (I (Kr))(,) the principal mechanism of drug‐associated arrhythmia. Congenital defects of inward rectifier K(+) current (I...

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Detalles Bibliográficos
Autores principales:	Klein, Michael G., Krantz, Mori J., Fatima, Naheed, Watters, Ashlie, Colon‐Sanchez, Dayan, Geiger, Robert M., Goldstein, Robert E., Solhjoo, Soroosh, Mehler, Philip S., Flagg, Thomas P., Haigney, Mark C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238736/ https://www.ncbi.nlm.nih.gov/pubmed/35658478 http://dx.doi.org/10.1161/JAHA.121.023482

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