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Autophagy Underlies the Proteostasis Mechanisms of Artemisinin Resistance in P. falciparum Malaria

Emerging resistance to artemisinin (ART) has become a challenge for reducing worldwide malaria mortality and morbidity. The C580Y mutation in Plasmodium falciparum Kelch13 has been identified as the major determinant for ART resistance in the background of other mutations, which include the T38I mut...

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Detalles Bibliográficos
Autores principales: Ray, Ananya, Mathur, Miti, Choubey, Deepak, Karmodiya, Krishanpal, Surolia, Namita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239046/
https://www.ncbi.nlm.nih.gov/pubmed/35420484
http://dx.doi.org/10.1128/mbio.00630-22