Evidence for an ACE2-Independent Entry Pathway That Can Protect from Neutralization by an Antibody Used for COVID-19 Therapy

SARS-CoV-2 variants of concern (VOC) acquired mutations in the spike (S) protein, including E484K, that confer resistance to neutralizing antibodies. However, it is incompletely understood how these mutations impact viral entry into host cells. Here, we analyzed how mutations at position 484 that ha...

Descripción completa

Detalles Bibliográficos
Autores principales: Hoffmann, Markus, Sidarovich, Anzhalika, Arora, Prerna, Krüger, Nadine, Nehlmeier, Inga, Kempf, Amy, Graichen, Luise, Winkler, Martin S., Niemeyer, Daniela, Goffinet, Christine, Drosten, Christian, Schulz, Sebastian, Jäck, Hans-Martin, Pöhlmann, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239067/
https://www.ncbi.nlm.nih.gov/pubmed/35467423
http://dx.doi.org/10.1128/mbio.00364-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239067/
https://www.ncbi.nlm.nih.gov/pubmed/35467423
http://dx.doi.org/10.1128/mbio.00364-22

Ejemplares similares