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Harnessing Rare Actinomycete Interactions and Intrinsic Antimicrobial Resistance Enables Discovery of an Unusual Metabolic Inhibitor

Bacterial natural products have historically been a deep source of new medicines, but their slowed discovery in recent decades has put a premium on developing strategies that enhance the likelihood of capturing novel compounds. Here, we used a straightforward approach that capitalizes on the interac...

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Detalles Bibliográficos
Autores principales: McClung, Dylan J., Du, Yongle, Antonich, Dominic J., Bonet, Bailey, Zhang, Wenjun, Traxler, Matthew F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239090/
https://www.ncbi.nlm.nih.gov/pubmed/35608300
http://dx.doi.org/10.1128/mbio.00393-22