Adenosine Awakens Metabolism to Enhance Growth-Independent Killing of Tolerant and Persister Bacteria across Multiple Classes of Antibiotics

Metabolic and growth arrest are primary drivers of antibiotic tolerance and persistence in clinically diverse bacterial pathogens. We recently showed that adenosine (ADO) suppresses bacterial growth under nutrient-limiting conditions. In the current study, we show that despite the growth-suppressive...

Descripción completa

Detalles Bibliográficos
Autores principales: Kitzenberg, David A., Lee, J. Scott, Mills, Krista B., Kim, Ju-Sim, Liu, Lin, Vázquez-Torres, Andrés, Colgan, Sean P., Kao, Daniel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239199/
https://www.ncbi.nlm.nih.gov/pubmed/35575513
http://dx.doi.org/10.1128/mbio.00480-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239199/
https://www.ncbi.nlm.nih.gov/pubmed/35575513
http://dx.doi.org/10.1128/mbio.00480-22

Ejemplares similares