Temsavir Treatment of HIV-1-Infected Cells Decreases Envelope Glycoprotein Recognition by Broadly Neutralizing Antibodies

The heavily glycosylated HIV-1 envelope glycoprotein (Env) is the sole viral antigen present at the surface of virions and infected cells, representing the main target for antibody responses. The FDA-approved small molecule temsavir acts as an HIV-1 attachment inhibitor by preventing Env-CD4 interac...

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Detalles Bibliográficos
Autores principales: Boutin, Marianne, Vézina, Dani, Ding, Shilei, Prévost, Jérémie, Laumaea, Annemarie, Marchitto, Lorie, Anand, Sai Priya, Medjahed, Halima, Gendron-Lepage, Gabrielle, Bourassa, Catherine, Goyette, Guillaume, Clark, Andrew, Richard, Jonathan, Finzi, Andrés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Observation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239219/
https://www.ncbi.nlm.nih.gov/pubmed/35475646
http://dx.doi.org/10.1128/mbio.00577-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239219/
https://www.ncbi.nlm.nih.gov/pubmed/35475646
http://dx.doi.org/10.1128/mbio.00577-22

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