Penicillanic Acid Sulfones Inactivate the Extended-Spectrum β-Lactamase CTX-M-15 through Formation of a Serine-Lysine Cross-Link: an Alternative Mechanism of β-Lactamase Inhibition

β-Lactamases hydrolyze β-lactam antibiotics and are major determinants of antibiotic resistance in Gram-negative pathogens. Enmetazobactam (formerly AAI101) and tazobactam are penicillanic acid sulfone (PAS) β-lactamase inhibitors that differ by an additional methyl group on the triazole ring of enm...

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Detalles Bibliográficos
Autores principales: Hinchliffe, Philip, Tooke, Catherine L., Bethel, Christopher R., Wang, Benlian, Arthur, Christopher, Heesom, Kate J., Shapiro, Stuart, Schlatzer, Daniela M., Papp-Wallace, Krisztina M., Bonomo, Robert A., Spencer, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239225/
https://www.ncbi.nlm.nih.gov/pubmed/35612361
http://dx.doi.org/10.1128/mbio.01793-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239225/
https://www.ncbi.nlm.nih.gov/pubmed/35612361
http://dx.doi.org/10.1128/mbio.01793-21

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