Gain-of-Signal Assays for Probing Inhibition of SARS-CoV-2 M(pro)/3CL(pro) in Living Cells

The main protease, M(pro), of SARS-CoV-2 is required to cleave the viral polyprotein into precise functional units for virus replication and pathogenesis. Here, we report quantitative reporters for M(pro) function in living cells in which protease inhibition by genetic or chemical methods results in...

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Detalles Bibliográficos
Autores principales: Moghadasi, Seyed Arad, Esler, Morgan A., Otsuka, Yuka, Becker, Jordan T., Moraes, Sofia N., Anderson, Constance B., Chamakuri, Srinivas, Belica, Christopher, Wick, Chloe, Harki, Daniel A., Young, Damian W., Scampavia, Louis, Spicer, Timothy P., Shi, Ke, Aihara, Hideki, Brown, William L., Harris, Reuben S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239272/
https://www.ncbi.nlm.nih.gov/pubmed/35471084
http://dx.doi.org/10.1128/mbio.00784-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239272/
https://www.ncbi.nlm.nih.gov/pubmed/35471084
http://dx.doi.org/10.1128/mbio.00784-22

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