Structural Basis of the Pancreatitis-Associated Autoproteolytic Failsafe Mechanism in Human Anionic Trypsin

OBJECTIVE: The pathophysiological mechanisms underlying chronic pancreatitis (CP) are still poorly understood. Human cationic (TRY1) and anionic (TRY2) trypsins are the two major trypsin isoforms and their activities are tightly regulated within pancreatic acinar cells. Typically, they exist in a mo...

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Detalles Bibliográficos
Autores principales: Nagel, Felix, Susemihl, Anne, Geist, Norman, Möhlis, Kevin, Palm, Gottfried J, Lammers, Michael, Delcea, Mihaela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239388/
https://www.ncbi.nlm.nih.gov/pubmed/35775010
http://dx.doi.org/10.2147/JIR.S367699

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239388/
https://www.ncbi.nlm.nih.gov/pubmed/35775010
http://dx.doi.org/10.2147/JIR.S367699

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