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Genomic features underlie the co-option of SVA transposons as cis-regulatory elements in human pluripotent stem cells
Domestication of transposable elements (TEs) into functional cis-regulatory elements is a widespread phenomenon. However, the mechanisms behind why some TEs are co-opted as functional enhancers while others are not are underappreciated. SINE-VNTR-Alus (SVAs) are the youngest group of transposons in...
Autores principales: | Barnada, Samantha M., Isopi, Andrew, Tejada-Martinez, Daniela, Goubert, Clément, Patoori, Sruti, Pagliaroli, Luca, Tracewell, Mason, Trizzino, Marco |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239442/ https://www.ncbi.nlm.nih.gov/pubmed/35704668 http://dx.doi.org/10.1371/journal.pgen.1010225 |
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