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All-atom molecular dynamics simulations of Synaptotagmin-SNARE-complexin complexes bridging a vesicle and a flat lipid bilayer

Synaptic vesicles are primed into a state that is ready for fast neurotransmitter release upon Ca(2+)-binding to Synaptotagmin-1. This state likely includes trans-SNARE complexes between the vesicle and plasma membranes that are bound to Synaptotagmin-1 and complexins. However, the nature of this st...

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Detalles Bibliográficos
Autores principales: Rizo, Josep, Sari, Levent, Qi, Yife, Im, Wonpil, Lin, Milo M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239685/
https://www.ncbi.nlm.nih.gov/pubmed/35708237
http://dx.doi.org/10.7554/eLife.76356