Pathogenic SLC25A26 variants impair SAH transport activity causing mitochondrial disease

The SLC25A26 gene encodes a mitochondrial inner membrane carrier that transports S-adenosylmethionine (SAM) into the mitochondrial matrix in exchange for S-adenosylhomocysteine (SAH). SAM is the predominant methyl-group donor for most cellular methylation processes, of which SAH is produced as a by-...

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Detalles Bibliográficos
Autores principales: Rosenberger, Florian A, Tang, Jia Xin, Sergeant, Kate, Moedas, Marco F, Zierz, Charlotte M, Moore, David, Smith, Conrad, Lewis, David, Guha, Nishan, Hopton, Sila, Falkous, Gavin, Lam, Amanda, Pyle, Angela, Poulton, Joanna, Gorman, Gráinne S, Taylor, Robert W, Freyer, Christoph, Wredenberg, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239748/
https://www.ncbi.nlm.nih.gov/pubmed/35024855
http://dx.doi.org/10.1093/hmg/ddac002

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239748/
https://www.ncbi.nlm.nih.gov/pubmed/35024855
http://dx.doi.org/10.1093/hmg/ddac002

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