Single-nucleotide polymorphisms and the effectiveness of taxane-based chemotherapy in premenopausal breast cancer: a population-based cohort study in Denmark

PURPOSE: Taxane-based chemotherapy is the primary treatment for premenopausal breast cancer. Although being inconsistent, research suggests that variant alleles alter pharmacokinetics through reduced function of OATP transporters (limiting hepatic uptake), CYP-450 enzymes (hampering drug metabolism)...

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Detalles Bibliográficos
Autores principales: Hjorth, Cathrine F., Damkier, Per, Stage, Tore B., Feddersen, Søren, Hamilton-Dutoit, Stephen, Rørth, Mikael, Ejlertsen, Bent, Lash, Timothy L., Ahern, Thomas P., Sørensen, Henrik T., Cronin-Fenton, Deirdre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239972/
https://www.ncbi.nlm.nih.gov/pubmed/35501422
http://dx.doi.org/10.1007/s10549-022-06596-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239972/
https://www.ncbi.nlm.nih.gov/pubmed/35501422
http://dx.doi.org/10.1007/s10549-022-06596-2

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