Cargando…

Evolution and activation mechanism of the flavivirus class II membrane-fusion machinery

The flavivirus envelope glycoproteins prM and E drive the assembly of icosahedral, spiky immature particles that bud across the membrane of the endoplasmic reticulum. Maturation into infectious virions in the trans-Golgi network involves an acid-pH-driven rearrangement into smooth particles made of...

Descripción completa

Detalles Bibliográficos
Autores principales: Vaney, Marie-Christine, Dellarole, Mariano, Duquerroy, Stéphane, Medits, Iris, Tsouchnikas, Georgios, Rouvinski, Alexander, England, Patrick, Stiasny, Karin, Heinz, Franz X., Rey, Félix A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239988/
https://www.ncbi.nlm.nih.gov/pubmed/35764616
http://dx.doi.org/10.1038/s41467-022-31111-y