Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation

Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions. We aimed to dissect the role of glycogen degradation in glioblastoma (GBM) response to ionising radiation (IR). Knockdown of the glycogen...

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Detalles Bibliográficos
Autores principales: Zois, Christos E., Hendriks, Anne M., Haider, Syed, Pires, Elisabete, Bridges, Esther, Kalamida, Dimitra, Voukantsis, Dimitrios, Lagerholm, B. Christoffer, Fehrmann, Rudolf S. N., den Dunnen, Wilfred F. A., Tarasov, Andrei I., Baba, Otto, Morris, John, Buffa, Francesca M., McCullagh, James S. O., Jalving, Mathilde, Harris, Adrian L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240045/
https://www.ncbi.nlm.nih.gov/pubmed/35764612
http://dx.doi.org/10.1038/s41419-022-05005-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240045/
https://www.ncbi.nlm.nih.gov/pubmed/35764612
http://dx.doi.org/10.1038/s41419-022-05005-2

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