Cargando…

Liver glycogen phosphorylase is upregulated in glioblastoma and provides a metabolic vulnerability to high dose radiation

Channelling of glucose via glycogen, known as the glycogen shunt, may play an important role in the metabolism of brain tumours, especially in hypoxic conditions. We aimed to dissect the role of glycogen degradation in glioblastoma (GBM) response to ionising radiation (IR). Knockdown of the glycogen...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zois, Christos E., Hendriks, Anne M., Haider, Syed, Pires, Elisabete, Bridges, Esther, Kalamida, Dimitra, Voukantsis, Dimitrios, Lagerholm, B. Christoffer, Fehrmann, Rudolf S. N., den Dunnen, Wilfred F. A., Tarasov, Andrei I., Baba, Otto, Morris, John, Buffa, Francesca M., McCullagh, James S. O., Jalving, Mathilde, Harris, Adrian L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240045/ https://www.ncbi.nlm.nih.gov/pubmed/35764612 http://dx.doi.org/10.1038/s41419-022-05005-2

Ejemplares similares

The role of glycogen phosphorylase in glycogen biogenesis in skeletal muscle after exercise
por: Katz, Abram
Publicado: (2022)

ADGRL4/ELTD1 Silencing in Endothelial Cells Induces ACLY and SLC25A1 and Alters the Cellular Metabolic Profile
por: Favara, David M., et al.
Publicado: (2019)

Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
por: de Heer, E. C., et al.
Publicado: (2023)

Correction: Glycogen synthase 1 targeting reveals a metabolic vulnerability in triple-negative breast cancer
por: de Heer, E. C., et al.
Publicado: (2023)

Hexokinase 2, Glycogen Synthase and Phosphorylase Play a Key Role in Muscle Glycogen Supercompensation
por: Irimia, José M., et al.
Publicado: (2012)

Muscle Glycogen Phosphorylase and Its Functional Partners in Health and Disease
por: Migocka-Patrzałek, Marta, et al.
Publicado: (2021)

Optimization and Validation of an In Vitro Standardized Glycogen Phosphorylase Activity Assay
por: Rocha, Sónia, et al.
Publicado: (2021)

Glycogen phosphorylase inhibition improves cognitive function of aged mice
por: Drulis‐Fajdasz, Dominika, et al.
Publicado: (2023)

The Structure of Phosphorylase Kinase Holoenzyme at 9.9 Å Resolution and Location of the Catalytic Subunit and the Substrate Glycogen Phosphorylase
por: Vénien-Bryan, Catherine, et al.
Publicado: (2009)

Manipulating the Expression of Glycogen Phosphorylase in Synechococcus elongatus PCC 7942 to Mobilize Glycogen Storage for Sucrose Synthesis
por: Dan, Yu, et al.
Publicado: (2022)

ROLE OF THE SARCOPLASMIC RETICULUM IN GLYCOGEN METABOLISM : Binding of Phosphorylase, Phosphorylase Kinase, and Primer Complexes to the Sarcovesicles of Rabbit Skeletal Muscle
por: Wanson, Jean-Claude, et al.
Publicado: (1972)

Elevated Concentrations of Brain‐type Glycogen Phosphorylase in Renal Cell Carcinoma
por: Takashi, Munehisa, et al.
Publicado: (1989)

Glycogen Phosphorylase Isoenzyme Bb, Myoglobin and BNP in ANT-Induced Cardiotoxicity
por: Di, Jia-Yin, et al.
Publicado: (2018)

An In Silico and an In Vitro Inhibition Analysis of Glycogen Phosphorylase by Flavonoids, Styrylchromones, and Pyrazoles
por: Rocha, Sónia, et al.
Publicado: (2022)

Analysis of the expression, function and signaling of glycogen phosphorylase isoforms in hepatocellular carcinoma
por: Jiang, Lingyu, et al.
Publicado: (2022)

Metabolic sensitivity of pancreatic tumour cell apoptosis to glycogen phosphorylase inhibitor treatment
por: Lee, W-N P, et al.
Publicado: (2004)

Brain Isoform Glycogen Phosphorylase as a Novel Hepatic Progenitor Cell Marker
por: Huang, Yu-Wen, et al.
Publicado: (2015)

A thermal after-effect of UV irradiation of muscle glycogen phosphorylase b
por: Mikhaylova, Valeriya V., et al.
Publicado: (2017)

Anomeric Spironucleosides of β-d-Glucopyranosyl Uracil as Potential Inhibitors of Glycogen Phosphorylase
por: Stathi, Aggeliki, et al.
Publicado: (2019)

Molecular docking analysis of glycogen phosphorylase with inhibitors from Cissampelos pareira Linn.
por: Chandrashekar, Kirubhanand, et al.
Publicado: (2021)

Effect of Betaine and Arginine on Interaction of αB-Crystallin with Glycogen Phosphorylase b
por: Eronina, Tatiana B., et al.
Publicado: (2022)

Allosteric Regulation of Glycogen Phosphorylase by Order/Disorder Transition of the 250′ and 280s Loops
por: Kish, Monika, et al.
Publicado: (2023)

Quantification of the glycogen cascade system: the ultrasensitive responses of liver glycogen synthase and muscle phosphorylase are due to distinctive regulatory designs
por: Mutalik, Vivek K, et al.
Publicado: (2005)

KIAA1199 interacts with glycogen phosphorylase kinase β-subunit (PHKB) to promote glycogen breakdown and cancer cell survival
por: Terashima, Masato, et al.
Publicado: (2014)

Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes
por: Altemus, Megan A., et al.
Publicado: (2019)

Liver Glycogen Phosphorylase Deficiency Leads to Profibrogenic Phenotype in a Murine Model of Glycogen Storage Disease Type VI
por: Wilson, Lane H., et al.
Publicado: (2019)

Brain-Type Glycogen Phosphorylase Is Crucial for Astrocytic Glycogen Accumulation in Chronic Social Defeat Stress-Induced Depression in Mice
por: Zhu, Yuanyuan, et al.
Publicado: (2022)

Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells
por: Kawashima, Masahiro, et al.
Publicado: (2020)

Correction to: Disruption of hypoxia-inducible fatty acid binding protein 7 induces beige fat-like differentiation and thermogenesis in breast cancer cells
por: Kawashima, Masahiro, et al.
Publicado: (2020)

Species identification of silks by protein mass spectrometry reveals evidence of wild silk use in antiquity
por: Lee, Boyoung, et al.
Publicado: (2022)

Glycogen phosphorylase isoenzyme BB in the diagnosis of acute myocardial infarction: a meta-analysis
por: Lippi, Giuseppe, et al.
Publicado: (2013)

Design, Synthesis, and Use of Novel Photoaffinity Probes in Measuring the Serum Concentration of Glycogen Phosphorylase
por: Zhang, Yuchao, et al.
Publicado: (2019)

Linc-RAM promotes muscle cell differentiation via regulating glycogen phosphorylase activity
por: Zhai, Lili, et al.
Publicado: (2022)

Estrogen Receptor Involvement in Noradrenergic Regulation of Ventromedial Hypothalamic Nucleus Glucoregulatory Neurotransmitter and Stimulus-Specific Glycogen Phosphorylase Enzyme Isoform Expression
por: Mahmood, A. S. M. H., et al.
Publicado: (2020)

Association of glycogen synthase phosphatase and phosphorylase phosphatase activities with membranes of hepatic smooth endoplasmic reticulum
Publicado: (1979)

Induction of Protective Immunity against Chlamydia muridarum Intravaginal Infection with a Chlamydial Glycogen Phosphorylase
por: Li, Zhihong, et al.
Publicado: (2012)

Toxoplasma gondii Requires Glycogen Phosphorylase for Balancing Amylopectin Storage and for Efficient Production of Brain Cysts
por: Sugi, Tatsuki, et al.
Publicado: (2017)

The different expression of glycogen phosphorylases in renal clear cell renal carcinoma and chromophobe renal carcinoma
por: Lu, Yang, et al.
Publicado: (2020)

Human hair follicles operate an internal Cori cycle and modulate their growth via glycogen phosphorylase
por: Figlak, Katarzyna, et al.
Publicado: (2021)

Diagnostic accuracy of glycogen phosphorylase BB for myocardial infarction: A systematic review and meta‐analysis
por: Ghimire, Anup, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_s951rj9e97cfgl2csre5r2886a