Clonal reconstruction from co-occurrence of vector integration sites accurately quantifies expanding clones in vivo

High transduction rates of viral vectors in gene therapies (GT) and experimental hematopoiesis ensure a high frequency of gene delivery, although multiple integration events can occur in the same cell. Therefore, tracing of integration sites (IS) leads to mis-quantification of the true clonal spectr...

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Detalles Bibliográficos
Autores principales: Wagner, Sebastian, Baldow, Christoph, Calabria, Andrea, Rudilosso, Laura, Gallina, Pierangela, Montini, Eugenio, Cesana, Daniela, Glauche, Ingmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240075/
https://www.ncbi.nlm.nih.gov/pubmed/35764632
http://dx.doi.org/10.1038/s41467-022-31292-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240075/
https://www.ncbi.nlm.nih.gov/pubmed/35764632
http://dx.doi.org/10.1038/s41467-022-31292-6

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